Analysis of ISG expression in chronic hepatitis C identifies viperin as a potential antiviral effector

@article{Helbig2005AnalysisOI,
  title={Analysis of ISG expression in chronic hepatitis C identifies viperin as a potential antiviral effector},
  author={K. Helbig and D. T. Lau and L. Semendric and H. Harley and M. R. Beard},
  journal={Hepatology},
  year={2005},
  volume={42}
}
  • K. Helbig, D. T. Lau, +2 authors M. R. Beard
  • Published 2005
  • Biology, Medicine
  • Hepatology
  • Interferon (IFN) α inhibits hepatitis C virus (HCV) replication both clinically and in vitro; however, the complete spectrum of interferon‐stimulated genes (ISGs) expressed in the HCV‐infected liver or the genes responsible for control of HCV replication have not been defined. To better define ISG expression in the chronically infected HCV liver, DNA microarray analysis was performed on 9 individuals with chronic hepatitis C (CHC). A total of 232 messenger RNAs were differentially regulated in… CONTINUE READING
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