Analysis of Hypericin-Mediated Effects and Implications for Targeted Photodynamic Therapy

Abstract

The phototoxic effect of hypericin can be utilized for Photodynamic Therapy (PDT) of cancer. After intravenous application and systemic distribution of the drug in the patient's body, the tumor site is exposed to light. Subsequently, toxic reactive oxygen species (ROS) are generated, inducing tumor cell death. To prevent unwanted activation of the drug in… (More)
DOI: 10.3390/ijms18071388

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7 Figures and Tables