Analysis of Host-Mediated Repair Mechanisms after Human CNS-Stem Cell Transplantation for Spinal Cord Injury: Correlation of Engraftment with Recovery

@article{Hooshmand2009AnalysisOH,
  title={Analysis of Host-Mediated Repair Mechanisms after Human CNS-Stem Cell Transplantation for Spinal Cord Injury: Correlation of Engraftment with Recovery},
  author={Mitra J Hooshmand and Christopher J. Sontag and Nobuko Uchida and Stan J Tamaki and Aileen J Anderson and Brian J Cummings},
  journal={PLoS ONE},
  year={2009},
  volume={4},
  pages={14069 - 14074}
}
BACKGROUND Human central nervous system-stem cells grown as neurospheres (hCNS-SCns) self-renew, are multipotent, and have potential therapeutic applications following trauma to the spinal cord. We have previously shown locomotor recovery in immunodeficient mice that received a moderate contusion spinal cord injury (SCI) and hCNS-SCns transplantation 9 days post-injury (dpi). Engrafted hCNS-SCns exhibited terminal differentiation to myelinating oligodendrocytes and synapse-forming neurons… CONTINUE READING

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References

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Showing 1-10 of 106 references

Quantitative study of neurofilament-positive fiber length in rat spinal cord lesions using isotropic virtual planes

  • M von Euler, JO Larsen, AM Janson
  • J Comp Neurol
  • 1998
Highly Influential
7 Excerpts

Quantative analysis of cellular inflammation after spinal cord injury: evidence for a multiphasic inflammatory response in the acute to chronic environment

  • HX Nguyen, KD Beck, MD Galvan, DL Salazar, AJ Anderson
  • 2008
2 Excerpts

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