Analysis of HLA haplotypes in autoimmune hepatitis type 1: identifying the major susceptibility locus.

@article{Goldberg2001AnalysisOH,
  title={Analysis of HLA haplotypes in autoimmune hepatitis type 1: identifying the major susceptibility locus.},
  author={Anna Carla Goldberg and Paulo R L Bittencourt and Bruno Mougin and Eduardo L. R Cançado and Gilda Porta and Flair Jos{\'e} Carrilho and Jorge Agle Kalil},
  journal={Human immunology},
  year={2001},
  volume={62 2},
  pages={165-9}
}
Susceptibility to autoimmune hepatitis type I (AIH-1) has been associated with HLA-DR3, DR52, and DR4 antigens in Caucasian and Oriental patients. However, in Brazil, disease susceptibility is primarily linked to DR13 and DR52. In this highly admixed population, we find different DR13-associated haplotypes, presenting a unique opportunity to discriminate relevant genes within a tightly linked genomic region. To identify the primary susceptibility locus, we sequenced DR13 alleles of 39 patients… CONTINUE READING

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