Analysis of HLA-DR matching in DNA-typed cadaver kidney transplants.

@article{Opelz1993AnalysisOH,
  title={Analysis of HLA-DR matching in DNA-typed cadaver kidney transplants.},
  author={Gerhard Opelz and Joannis Mytilineos and Sabine Scherer and Heather Dunckley and Jean Trejaut and Jeremy Chapman and Gottfried Fischer and Ingrid Fa{\'e} and Derek Middleton and D F Savage},
  journal={Transplantation},
  year={1993},
  volume={55 4},
  pages={782-5}
}
The effect of matching for HLA-DR antigens was analyzed retrospectively in 3455 cadaver kidney transplants that were typed by the DNA-RFLP method. HLA-DR matching improved the one-year graft survival rate significantly (P < 0.01). Importantly, in 718 first transplants in which the number of mismatches assigned by serological typing was different from that assigned by DNA typing, only the DNA results showed a significant impact of matching on graft outcome (P = 0.03). These results demonstrate… CONTINUE READING