Analysis of Gene Expression Data with Pathway Scores

@article{Zien2000AnalysisOG,
  title={Analysis of Gene Expression Data with Pathway Scores},
  author={Alexander Zien and Robert K{\"u}ffner and Ralf Zimmer and Thomas Lengauer},
  journal={Proceedings. International Conference on Intelligent Systems for Molecular Biology},
  year={2000},
  volume={8},
  pages={407-17}
}
We present a new approach for the evaluation of gene expression data. The basic idea is to generate biologically possible pathways and to score them with respect to gene expression measurements. We suggest sample scoring functions for different problem specifications. We assess the significance of the scores for the investigated pathways by comparison to a number of scores for random pathways. We show that simple scoring functions can assign statistically significant scores to biologically… CONTINUE READING
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A comprehensive analysis of protein-protein interactions in saccharomyces cerevisiae

  • J. M. Rothberg
  • Nature
  • 2000

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