Analysis of GSTM1, GSTT1, and CYP1A1 in idiopathic male infertility.

  title={Analysis of GSTM1, GSTT1, and CYP1A1 in idiopathic male infertility.},
  author={Zivar Salehi and Lida Gholizadeh and Hamidreza Vaziri and Ali Hamidi Madani},
  journal={Reproductive sciences},
  volume={19 1},
Enzymes belonging to the glutathione-S-transferase (GST) and cytochrome P450 (CYP) families are involved in a 2-stage detoxification process of a wide range of environmental toxins and carcinogens. In order to investigate whether there is a genetic association of the biotransformation enzymes and idiopathic male fertility, we studied GSTT1, GSTM1, and CYP1A1*2A polymorphisms in 150 infertile men and 200 healthy men as controls from Northern Iran. Genotyping of the GSTT1 and GSTM1 genes were… CONTINUE READING