Analysis of GNAQ mutations, proliferation and MAPK pathway activation in uveal melanomas.

Abstract

AIM To study the GNAQ mutational status in a series of uveal melanomas and evaluate possible associations with mitogen-activated protein kinase (MAPK) pathway protein expression and tumour proliferation markers. METHODS Mutational analysis was performed by PCR/sequencing of exon 5 of the GNAQ gene in a series of 22 uveal melanomas in which total and… (More)
DOI: 10.1136/bjo.2009.174417

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Cite this paper

@article{Ppulo2011AnalysisOG, title={Analysis of GNAQ mutations, proliferation and MAPK pathway activation in uveal melanomas.}, author={Helena P{\'o}pulo and Jo{\~a}o Vinagre and Jose Lopes and Paula Soares}, journal={The British journal of ophthalmology}, year={2011}, volume={95 5}, pages={715-9} }