Analysis of G(-174)C IL-6 polymorphism and plasma concentrations of inflammatory markers in patients with type 2 diabetes and peripheral arterial disease.

@article{Libra2006AnalysisOG,
  title={Analysis of G(-174)C IL-6 polymorphism and plasma concentrations of inflammatory markers in patients with type 2 diabetes and peripheral arterial disease.},
  author={Massimo Libra and Santo Salvatore Signorelli and Ylenia Bevelacqua and Patrick Michael Navolanic and Valentina Bevelacqua and Jerry Polesel and Renato Talamini and Franca Stivala and Maria Clorinda Mazzarino and Graziella Malaponte},
  journal={Journal of clinical pathology},
  year={2006},
  volume={59 2},
  pages={211-5}
}
AIMS To determine whether the G(-174)C interleukin 6 (IL-6) polymorphism influences the development of peripheral arterial disease (PAD) in individuals with type 2 diabetes. This was investigated by comparing the distribution of G(-174)C genotypes between patients with type 2 diabetes and PAD (PAD+) and those with type 2 diabetes but without PAD (PAD-). Plasma concentrations of IL-6, fibrinogen, C reactive protein (CRP), and vascular endothelial growth factor (VEGF) were also compared in PAD… CONTINUE READING

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