Analysis of FGFR3 gene mutations in multiple myeloma patients with t(4;14).

  title={Analysis of FGFR3 gene mutations in multiple myeloma patients with t(4;14).},
  author={Daniela Intini and Luca Baldini and Sonia Fabris and Luigia Lombardi and Gabriella Ciceri and Anna Teresa Maiolo and Antonino Neri},
  journal={British journal of haematology},
  volume={114 2},
The t(4;14)(p16.3;q32) in multiple myeloma (MM) leads to an apparent deregulation of the FGFR3 and WHSC1/MMSET genes. FGFR3 mutations, known to be associated with genetic skeletal disorders, have also been identified in a few cases of MM (mainly cell lines) with t(4;14). We investigated FGFR3 mutations in a series of 53 MM cases; 11 cases with t(4;14) and FGFR3 overexpression were analysed using reverse transcription polymerase chain reaction, while the remaining cases were studied at DNA level… CONTINUE READING

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