Analysis of ESR1 mutation in circulating tumor DNA demonstrates evolution during therapy for metastatic breast cancer

@article{Schiavon2015AnalysisOE,
  title={Analysis of ESR1 mutation in circulating tumor DNA demonstrates evolution during therapy for metastatic breast cancer},
  author={Gaia Schiavon and Sarah Hrebien and Isaac Garcia-Murillas and Rosalind J. Cutts and Alex Pearson and Noelia Tarazona and Kerry Fenwick and Iwanka Kozarewa and Elena L{\'o}pez-Knowles and Ricardo C Ribas and Ashutosh Nerurkar and Peter Osin and Sarat Chandarlapaty and Lesley-Ann Martin and Mitch Dowsett and Ian E. Smith and Nicholas C. Turner},
  journal={Science Translational Medicine},
  year={2015},
  volume={7},
  pages={313ra182-313ra182}
}
Acquired ESR1 mutations are a major mechanism of resistance to aromatase inhibitors (AIs). We developed ultra high–sensitivity multiplex digital polymerase chain reaction assays for ESR1 mutations in circulating tumor DNA (ctDNA) and investigated the clinical relevance and origin of ESR1 mutations in 171 women with advanced breast cancer. ESR1 mutation status in ctDNA showed high concordance with contemporaneous tumor biopsies and was accurately assessed in samples shipped at room temperature… CONTINUE READING
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ScienceTr estrogen receptor 1 ( ESR 1 ) mutations in estrogen receptor – positive metastatic breast cancer

  • B. Mussolin G. Siravegna, M. Buscarino, +28 authors A. Bardelli
  • Clin . Chem .
  • 2015

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