Analysis of Determinants in Filovirus Glycoproteins Required for Tetherin Antagonism

@inproceedings{Gnir2014AnalysisOD,
  title={Analysis of Determinants in Filovirus Glycoproteins Required for Tetherin Antagonism},
  author={Kerstin Gnir{\ss} and Marie Fiedler and Annika Kr{\"a}mer-K{\"u}hl and Sebastian Bolduan and Eva Mittler and Stephan Becker and Michael Schindler and Stefan P{\"o}hlmann},
  booktitle={Viruses},
  year={2014}
}
The host cell protein tetherin can restrict the release of enveloped viruses from infected cells. The HIV-1 protein Vpu counteracts tetherin by removing it from the site of viral budding, the plasma membrane, and this process depends on specific interactions between the transmembrane domains of Vpu and tetherin. In contrast, the glycoproteins (GPs) of two filoviruses, Ebola and Marburg virus, antagonize tetherin without reducing surface expression, and the domains in GP required for tetherin… CONTINUE READING
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