Analysis of DNA and hemoglobin adducts and sister chromatid exchanges in a human population occupationally exposed to propylene oxide: a pilot study.

@article{Czene2002AnalysisOD,
  title={Analysis of DNA and hemoglobin adducts and sister chromatid exchanges in a human population occupationally exposed to propylene oxide: a pilot study.},
  author={Kamila Czene and Siv M Osterman-Golkar and Xiao Yun and Gang Li and Fulin Zhao and Hermes Licea P{\'e}rez and Ming Li and Adayapalam Tyagarajan Natarajan and Dan Segerb{\"a}ck},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  year={2002},
  volume={11 3},
  pages={
          315-8
        }
}
Propylene oxide (PO), a simple alkylating agent used in the chemical industry, is weakly genotoxic and induces nasal cavity tumors in rodents on inhalation at high air concentrations. DNA adducts, hemoglobin adducts, and sister chromatid exchanges (SCE) were analyzed as biomarkers of exposure in a group of eight PO-exposed workers and eight nonexposed subjects. 1-2-Hydroxypropyladenine (1-HP-adenine) in DNA of WBCs was analyzed using a hypersensitive (32)P-postlabeling assay. HP-valine in… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-7 of 7 citations

References

Publications referenced by this paper.
Showing 1-10 of 21 references

Propylene oxide: its relationship to mutagenesis, carcinogenesis and molecular dose

  • M. N. Rı́os-Blanco, K. Plná, +7 authors J. A. Swenberg
  • Mutat. Res.,
  • 1997
1 Excerpt

on the Evaluation of Carcinogenic Risk of Chemicals to Humans, Vol

  • IARC. Monograph
  • 60, pp. 181–213. Lyon, France: IARC,
  • 1994
1 Excerpt