Analysis of Cytochrome P 450 2 E 1 Genetic Polymorphisms in Relation to Human Lung Cancer

@inproceedings{Kato2005AnalysisOC,
  title={Analysis of Cytochrome P 450 2 E 1 Genetic Polymorphisms in Relation to Human Lung Cancer},
  author={Shunji Kato and Peter G. Shields and Neil E. Caporaso and Haruhiko Sugimura and Glenwood E. Trivers and Margaret A. Tucker and Benjamin F. Trump and Ainsley Weston and Curtis C. Harris},
  year={2005}
}
Human cancer risk assessment using molecular genetic techniques is a rapidly emerging field. Many studies suggest that both inherited and acquired genetic predispositions play an important role in carcinogenesis. Cytochrome P450 (CYP) 2E1 is involved in the metabolic activation of N-nitrosamines and other low molecular weight compounds. A recently described genetic polymorphism of CYP2E1 [Dral restriction fragment length polymorphism (RFLP)] has been associated with an increased risk of lung… CONTINUE READING