Analysis of Creatine Kinase Activity in 504 Patients with Proximal Spinal Muscular Atrophy Types I–III from the Point of View of Progression and Severity

@article{RudnikSchneborn1998AnalysisOC,
  title={Analysis of Creatine Kinase Activity in 504 Patients with Proximal Spinal Muscular Atrophy Types I–III from the Point of View of Progression and Severity},
  author={Sabine Rudnik-Sch{\"o}neborn and Susanne L{\"u}tzenrath and Janina Borkowska and A. Karwańska and Irena Hausmanowa-Petrusewicz and Klaus Zerres},
  journal={European Neurology},
  year={1998},
  volume={39},
  pages={154 - 162}
}
Mild to moderately elevated creatine kinase (CK) activity is a frequent biochemical finding in proximal spinal muscular atrophy (SMA). In a collaborative study on all types of childhood and juvenile onset SMA, we analysed the CK activity of 504 SMA patients (138 type I, 127 type II, 144 type IIIa, and 95 type IIIb patients). Under the assumption of a lognormal distribution of CK activity as the most appropriate statistical model, CK levels were transformed into logarithms and compared by… 

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