Analysis of Complexation Interactions between Metal Ions and Drugs Under Pseudo-physiological pH Conditions by a High-throughput Screening Method Using a Solid-phase Extraction Cartridge.

@article{Moriiwa2019AnalysisOC,
  title={Analysis of Complexation Interactions between Metal Ions and Drugs Under Pseudo-physiological pH Conditions by a High-throughput Screening Method Using a Solid-phase Extraction Cartridge.},
  author={Yukiko Moriiwa and Naoko Suzuki and Atsushi Shoji and Akio Yanagida},
  journal={Analytical sciences : the international journal of the Japan Society for Analytical Chemistry},
  year={2019}
}
  • Yukiko Moriiwa, N. Suzuki, +1 author A. Yanagida
  • Published 20 December 2019
  • Chemistry, Medicine
  • Analytical sciences : the international journal of the Japan Society for Analytical Chemistry
A high-throughput screening method for the complexation between metal ions and drugs was established by combining solid-phase extraction (SPE) using a nitrilotriacetic acid (NTA) modified silica spin cartridge with subsequent HPLC analysis. First, a test metal ion solution was passed through the NTA cartridge, then a test drug solution diluted in phosphate buffered saline (pH 7.4) was passed through the metal-chelated NTA cartridge. The complexation behavior between the metal and the drug on… 

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