Analysis of CD8+ Treg cells in patients with ovarian cancer: a possible mechanism for immune impairment

@inproceedings{Zhang2015AnalysisOC,
  title={Analysis of CD8+ Treg cells in patients with ovarian cancer: a possible mechanism for immune impairment},
  author={Shuping Zhang and Xing Ke and Suyun Zeng and Meng Wu and Jianfang Lou and Lei Wu and Peijun Huang and Lei Huang and Fang Wang and Shi-yang Pan},
  booktitle={Cellular and Molecular Immunology},
  year={2015}
}
Regulatory T (Treg) cells may participate in mediating a suppressive microenvironment that blunts successful anti-tumor immunotherapy. Recent studies show that CD8+ Treg cells might impede effective immune responses to established tumors. However, there is limited research regarding CD8+ Treg cells in ovarian cancer (OC) patients. Here, we investigated CD8+ Treg cells in OC patients and their in vitro induction. The immunohistochemistry of tumor-infiltrating lymphocytes revealed a significant… CONTINUE READING
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