We have expressed the human CD4 and CD2 molecules in a murine hybridoma, 155.16, that responds to stimulation with human HLA-DR antigens by producing interleukin 2 (IL-2). When stimulated by HLA-DR expressing human cells, the CD4+ and CD2+ hybridomas produce significantly more IL-2 than the parent hybridomas, indicating that CD4 and CD2 are functional. We… (More)
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