Analysis of CD4+ T cells that provide contact-dependent bystander help to B cells.

@article{Croft1992AnalysisOC,
  title={Analysis of CD4+ T cells that provide contact-dependent bystander help to B cells.},
  author={Michael Croft and Susan L Swain},
  journal={Journal of immunology},
  year={1992},
  volume={149 10},
  pages={
          3157-65
        }
}
Although cognate, MHC-restricted interaction of Th cells with Ag-presenting B cells provides effective help to a resting B cell, substantial B cell responses have also been seen with preactivated T cell clones that cannot recognize Ag on the B cell but apparently interact in a noncognate fashion (the bystander response). Here, we have investigated the ability of distinct Th cell subsets and T cells activated by different stimuli to support such bystander B cell responses. We have also… CONTINUE READING

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