Analysis of C. elegans NR2E nuclear receptors defines three conserved clades and ligand-independent functions

@inproceedings{Weber2011AnalysisOC,
  title={Analysis of C. elegans NR2E nuclear receptors defines three conserved clades and ligand-independent functions},
  author={Katherine P. Weber and Christopher G. Alvaro and G Michael Baer and Kristy L. Reinert and Genevieve Cheng and Sheila Clever and Bruce Wightman},
  booktitle={BMC Evolutionary Biology},
  year={2011}
}
BackgroundThe nuclear receptors (NRs) are an important class of transcription factors that are conserved across animal phyla. Canonical NRs consist of a DNA-binding domain (DBD) and ligand-binding domain (LBD). While most animals have 20–40 NRs, nematodes of the genus Caenorhabditis have experienced a spectacular proliferation and divergence of NR genes. The LBDs of evolutionarily-conserved Caenorhabditis NRs have diverged sharply from their Drosophila and vertebrate orthologs, while the DBDs… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 76 REFERENCES

[Genetics of Caenorhabditis elegans].

  • Nobuo Munakata
  • Biology, Medicine
  • Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme
  • 1989
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

The neighbor-joining method: a new method for reconstructing phylogenetic trees.

VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

Nuclear hormone receptors in nematodes: Evolution and function

VIEW 1 EXCERPT