Analysis of B Cell Repertoire Dynamics Following Hepatitis B Vaccination in Humans, and Enrichment of Vaccine-specific Antibody Sequences.

@article{Galson2015AnalysisOB,
  title={Analysis of B Cell Repertoire Dynamics Following Hepatitis B Vaccination in Humans, and Enrichment of Vaccine-specific Antibody Sequences.},
  author={Jacob D Galson and Johannes Tr{\"u}ck and Anna Fowler and Elizabeth A. Clutterbuck and M{\'a}rton M{\"u}nz and Vincenzo Cerundolo and Claudia Reinhard and Robbert G van der Most and Andrew J Pollard and Gerton Lunter and Dominic F. Kelly},
  journal={EBioMedicine},
  year={2015},
  volume={2 12},
  pages={
          2070-9
        }
}
Generating a diverse B cell immunoglobulin repertoire is essential for protection against infection. The repertoire in humans can now be comprehensively measured by high-throughput sequencing. Using hepatitis B vaccination as a model, we determined how the total immunoglobulin sequence repertoire changes following antigen exposure in humans, and compared this to sequences from vaccine-specific sorted cells. Clonal sequence expansions were seen 7 days after vaccination, which correlated with… CONTINUE READING

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