Analysis of Altered MicroRNA Expression Profiles in Proximal Renal Tubular Cells in Response to Calcium Oxalate Monohydrate Crystal Adhesion: Implications for Kidney Stone Disease

@inproceedings{Wang2014AnalysisOA,
  title={Analysis of Altered MicroRNA Expression Profiles in Proximal Renal Tubular Cells in Response to Calcium Oxalate Monohydrate Crystal Adhesion: Implications for Kidney Stone Disease},
  author={Bohan Wang and Bolin Wu and Jun Liu and Weimin Yao and Ding Chun Xia and Lu Li and Zhiqiang Chen and Zhangqun Ye and Xiao Yu},
  booktitle={PloS one},
  year={2014}
}
BACKGROUND Calcium oxalate monohydrate (COM) is the major crystalline component in kidney stones and its adhesion to renal tubular cells leads to tubular injury. However, COM-induced toxic effects in renal tubular cells remain ambiguous. MicroRNAs (miRNAs) play an important role in gene regulation at the posttranscriptional levels. OBJECTIVE The present study aimed to assess the potential changes in microRNAs of proximal renal tubular cells in response to the adhesion of calcium oxalate… CONTINUE READING

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