Analysis of Adenomatous Polyposis Coli Promoter Hypermethylation in Human Cancer 1

@inproceedings{Esteller2000AnalysisOA,
  title={Analysis of Adenomatous Polyposis Coli Promoter Hypermethylation in Human Cancer 1},
  author={Manel Esteller and Andrew Sparks and Minoru Toyota and Montserrat S{\'a}nchez-C{\'e}spedes and G. Capella and Miguel A. Peinado and Sara Gonzalez and Gemma Tarafa and David Sidransky and Stephen J. Meltzer and Stephen B. Baylin and James G. Herman},
  year={2000}
}
Germ-line mutations in the tumor suppressor geneAPC are associated with hereditary familial adenomatous polyposis (FAP), and somatic mutations are common in sporadic colorectal tumors. We now report that methylation in the promoter region of this gene constitutes an alternative mechanism for gene inactivation in colon and other tumors of the… CONTINUE READING