Analysis of ATP-citrate lyase and malic enzyme mutants of Yarrowia lipolytica points out the importance of mannitol metabolism in fatty acid synthesis.

@article{Dulermo2015AnalysisOA,
  title={Analysis of ATP-citrate lyase and malic enzyme mutants of Yarrowia lipolytica points out the importance of mannitol metabolism in fatty acid synthesis.},
  author={Thierry Dulermo and Zbigniew Lazar and R{\'e}mi Dulermo and Magdalena Rakicka and Ramedane Haddouche and Jean-Marc Nicaud},
  journal={Biochimica et biophysica acta},
  year={2015},
  volume={1851 9},
  pages={1107-17}
}
The role of the two key enzymes of fatty acid (FA) synthesis, ATP-citrate lyase (Acl) and malic enzyme (Mae), was analyzed in the oleaginous yeast Yarrowia lipolytica. In most oleaginous yeasts, Acl and Mae are proposed to provide, respectively, acetyl-CoA and NADPH for FA synthesis. Acl was mainly studied at the biochemical level but no strain depleted for… CONTINUE READING