Analysis of -675 4 g/5 G SERPINE1 and C-159T CD14 polymorphisms in house dust mite-allergic asthma patients.

@article{Kowal2008AnalysisO,
  title={Analysis of -675 4 g/5 G SERPINE1 and C-159T CD14 polymorphisms in house dust mite-allergic asthma patients.},
  author={K Kowal and Anna Bodzenta-Lukaszyk and Agnieszka Pampuch and Maciej Szmitkowski and Sebastian Zukowski and Maria Benedetta Donati and Licia Iacoviello},
  journal={Journal of investigational allergology & clinical immunology},
  year={2008},
  volume={18 4},
  pages={284-92}
}
BACKGROUND Experimental studies indicate that endogenous plasminogen activator inhibitor-1 (PAI-1, encoded by the gene SERPINE1) modulates the immune response to lipopolysaccharide (LPS). On the other hand, LPS induces PAI-1 secretion. Activation of individual cells by LPS is facilitated by CD14. The single nucleotide polymorphisms -675 4G/5G in SERPINE1 and C-159T in CD14 are major determinants of PAI-1 and CD14 expression, respectively. OBJECTIVE To evaluate the frequency of the -675 4G/5G… CONTINUE READING
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Expression of interleukin-4 receptor in bronchial asthma patients treated with specifi c immunotherapy (SIT)

  • K Kowal, J Osada, S Zukowski, M Dabrowska, LM DuBuske, A. Bodzenta-Lukaszyk
  • Ann Allergy Asthma Immunol. 2004;93:68-75
  • 2008
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