Analysis of 5' junctions of human LINE-1 and Alu retrotransposons suggests an alternative model for 5'-end attachment requiring microhomology-mediated end-joining.

@article{Zingler2005AnalysisO5,
  title={Analysis of 5' junctions of human LINE-1 and Alu retrotransposons suggests an alternative model for 5'-end attachment requiring microhomology-mediated end-joining.},
  author={Nora Zingler and Ute Willhoeft and Hans-Peter Brose and Volker U Schoder and Thomas Jahns and K. M. Hanschmann and Tammy A. Morrish and Johannes Loewer and Gerald G. Schumann},
  journal={Genome research},
  year={2005},
  volume={15 6},
  pages={780-9}
}
Insertion of the human non-LTR retrotransposon LINE-1 (L1) into chromosomal DNA is thought to be initiated by a mechanism called target-primed reverse transcription (TPRT). This mechanism readily accounts for the attachment of the 3'-end of an L1 copy to the genomic target, but the subsequent integration steps leading to the attachment of the 5'-end to the chromosomal DNA are still cause for speculation. By applying bioinformatics to analyze the 5' junctions of recent L1 insertions in the human… CONTINUE READING
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