Analysis of 5'-flanking region of human Smad4 (DPC4) gene.

  title={Analysis of 5'-flanking region of human Smad4 (DPC4) gene.},
  author={Ryoji Minami and Riko Kitazawa and Shuichiro Maeda and Sohei Kitazawa},
  journal={Biochimica et biophysica acta},
  volume={1443 1-2},
Among the transducers of the transforming growth factor (TGF)-beta/bone morphogenetic protein (BMP) receptor signaling proteins, Smad4 and Smad1 act together in BMP 2/4 signaling pathways, and Smad4 and Smad2 act in TGF-beta/activin signaling. To investigate how the Smad4 gene is regulated at the transcriptional level, we cloned and characterized its 5'-flanking region. The major transcription start site mapped by primer extension analysis was 132 bp upstream of the translation start site. The… CONTINUE READING


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