Analysis of 4-hydroxy-1-(3-pyridyl)-1-butanone (HPB)-releasing DNA adducts in human exfoliated oral mucosa cells by liquid chromatography-electrospray ionization-tandem mass spectrometry.

@article{Stepanov2013AnalysisO4,
  title={Analysis of 4-hydroxy-1-(3-pyridyl)-1-butanone (HPB)-releasing DNA adducts in human exfoliated oral mucosa cells by liquid chromatography-electrospray ionization-tandem mass spectrometry.},
  author={Irina Stepanov and John G Muzic and Chap T. Le and Erin Sebero and Peter W Villalta and Bin Ma and Joni Jensen and Dorothy M Hatsukami and Stephen S Hecht},
  journal={Chemical research in toxicology},
  year={2013},
  volume={26 1},
  pages={37-45}
}
Quantitation of DNA adducts could provide critical information on the relationship between exposure to tobacco smoke and cancer risk in smokers. In this study, we developed a robust and sensitive liquid chromatography-tandem mass spectrometry method for the analysis of 4-hydroxy-1-(3-pyridyl)-1-butanone (HPB)-releasing DNA adducts in human oral cells, a noninvasive source of DNA for biomarker studies. Isolated DNA undergoes acid hydrolysis, after which samples are purified by solid-phase… CONTINUE READING
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