Analysis of 3'-end variable region of the cagA gene in Helicobacter pylori isolated from Iranian population.

@article{Shokrzadeh2010AnalysisO3,
  title={Analysis of 3'-end variable region of the cagA gene in Helicobacter pylori isolated from Iranian population.},
  author={Leila Shokrzadeh and Kaveh Baghaei and Yoshio Yamaoka and Hossein Dabiri and Fereshteh Jafari and Navid Sahebekhtiari and Ali Tahami and M Sugimoto and Homayon Zojaji and Mohammad Reza Zali},
  journal={Journal of gastroenterology and hepatology},
  year={2010},
  volume={25 1},
  pages={172-7}
}
BACKGROUND AND AIMS The 3' region of the cagA gene, the most well-known virulence factor of Helicobacter pylori, contains Glu-Pro-Ile-Tyr-Ala (EPIYA) motifs. Four segments flanking the EPIYA motifs, EPIYA-A, -B, -C, or -D, were reported to play important roles in H. pylori-related gastroduodenal pathogenesis. The aim was to determine the roles of EPIYA segments in gastroduodenal pathogenesis in an Iranian population. METHODS A total of 92 cagA-positive Iranian strains isolated from dyspepsia… CONTINUE READING

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