Analysis of 25 underivatized amino acids in human plasma using ion-pairing reversed-phase liquid chromatography/time-of-flight mass spectrometry.

@article{Armstrong2007AnalysisO2,
  title={Analysis of 25 underivatized amino acids in human plasma using ion-pairing reversed-phase liquid chromatography/time-of-flight mass spectrometry.},
  author={Michael P. Armstrong and Karen R Jonscher and Nichole Reisdorph},
  journal={Rapid communications in mass spectrometry : RCM},
  year={2007},
  volume={21 16},
  pages={2717-26}
}
Amino acids in biological fluids have previously been shown to be detectable using liquid chromatography/electrospray ionization mass spectrometry (LC/ESI-MS) with perfluorinated acids as ion-pairing agents. To date, these studies have used precursor mass, retention time and tandem mass spectrometry (MS/MS) to identify and quantify amino acids. While this is a potentially powerful technique, we sought to adapt the method to time-of-flight (TOF)MS. A new application of a recently described… CONTINUE READING

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Rapid Commun. Mass Spectrom

  • M McCooeye, Z. Mester
  • Rapid Commun. Mass Spectrom
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