Analysis of 25-hydroxyvitamin D3-1alpha-hydroxylase in cervical tissue.

  title={Analysis of 25-hydroxyvitamin D3-1alpha-hydroxylase in cervical tissue.},
  author={Michael Friedrich and Carlos E. Villena-Heinsen and Roland Axt-Fliedner and Roland Meyberg and Wolfgang Tilgen and Werner Schmidt and Joerg Reichrath},
  journal={Anticancer research},
  volume={22 1A},
UNLABELLED 1,25(OH)2D3 suppresses proliferation and induces differentiation in various cell types, including epithelial cells. Recently, extrarenal activity of 1alpha-hydroxylase for 25(OH)D3 has been reported in various cell types including macrophages, keratinocytes and prostate and colon cancer cells. The aim of this study was to analyze the expression of 1alpha-hydroxylase for 25-hydroxyvitamin D3 in normal cervical samples and in cervical cancer, in order to investigate whether cervical… CONTINUE READING