Analysis by cDNA microarrays of altered gene expression in middle ears of rats following pneumococcal infection.


OBJECTIVE Streptococcus pneumoniae is the most common pathogen in otitis media. Infection of the middle ear with S. pneumoniae potentiates development of thick effusion in the middle ear which frequently causes hearing loss and communication disorders in children. What has changed immediately in the middle ear cleft following pneumococcal infection is… (More)


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