Analysis and verification of the HMGB1 signaling pathway

  title={Analysis and verification of the HMGB1 signaling pathway},
  author={Haijun Gong and Paolo Zuliani and Anvesh Komuravelli and James R. Faeder and Edmund M. Clarke},
  booktitle={BMC Bioinformatics},
Recent studies have found that overexpression of the High-mobility group box-1 (HMGB1) protein, in conjunction with its receptors for advanced glycation end products (RAGEs) and toll-like receptors (TLRs), is associated with proliferation of various cancer types, including that of the breast and pancreatic. We have developed a rule-based model of crosstalk between the HMGB1 signaling pathway and other key cancer signaling pathways. The model has been simulated using both ordinary differential… CONTINUE READING
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