Analysis and validation of proteomic data generated by tandem mass spectrometry

  title={Analysis and validation of proteomic data generated by tandem mass spectrometry},
  author={Alexey I. Nesvizhskii and Olga Vitek and Ruedi Aebersold},
  journal={Nature Methods},
The analysis of the large amount of data generated in mass spectrometry–based proteomics experiments represents a significant challenge and is currently a bottleneck in many proteomics projects. In this review we discuss critical issues related to data processing and analysis in proteomics and describe available methods and tools. We place special emphasis on the elaboration of results that are supported by sound statistical arguments. 

From This Paper

Figures, tables, and topics from this paper.

Explore Further: Topics Discussed in This Paper


Publications citing this paper.
Showing 1-10 of 247 extracted citations

Functional Proteomics

Methods in Molecular Biology • 2005
View 6 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 127 references

Development and validation of a spectral library searching method for peptide identification from MS/MS

H Lam
Proteomics 7, • 2007

Similar Papers

Loading similar papers…