Analysis and prediction of absorption profile including hepatic first-pass metabolism of N-methyltyramine, a potent stimulant of gastrin release present in beer, after oral ingestion in rats by gastrointestinal-transit-absorption model.

@article{Kimura2000AnalysisAP,
  title={Analysis and prediction of absorption profile including hepatic first-pass metabolism of N-methyltyramine, a potent stimulant of gastrin release present in beer, after oral ingestion in rats by gastrointestinal-transit-absorption model.},
  author={T. D. Kimura and Norio Iwasaki and Jun-ichi Yokoe and Shin Haruta and Yoshiaki Yokoo and Ken ichi Ogawara and Kazutaka Higaki},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2000},
  volume={28 5},
  pages={577-81}
}
The prediction method for the plasma concentration-time profile of N-methyltyramine (NMT), a potent stimulant of gastrin release present in beer after oral ingestion in rats was examined using the previously developed Gastrointestinal (GI)-Transit-Absorption Model, with the addition of a process of hepatic first-pass metabolism. Phenol red was used as a… CONTINUE READING