Analysis and pharmacokinetics of glycyrrhizic acid and glycyrrhetinic acid in humans and experimental animals
@article{Krhenbhl1994AnalysisAP, title={Analysis and pharmacokinetics of glycyrrhizic acid and glycyrrhetinic acid in humans and experimental animals}, author={S. Kr{\"a}henb{\"u}hl and F. Hasler and R. Krapf}, journal={Steroids}, year={1994}, volume={59}, pages={121-126} }
Glycyrrhizic acid (GZA) and glycyrrhetinic acid (GRA) can be determined rapidly and precisely by high-performance liquid chromatography (HPLC) in biological fluids and tissues from experimental animals and humans. From plasma and tissues, GZA and GRA are extracted by organic solvents and the extracts can directly be used for HPLC. From bile or urine, extraction and determination of GZA and GRA are more difficult due to interfering endogenous compounds and conjugation of GRA with glucuronides or… CONTINUE READING
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References
SHOWING 1-10 OF 35 REFERENCES
Rapid estimation of glycyrrhizin and glycyrrhetinic acid in plasma by high-speed liquid chromatography.
- Chemistry, Medicine
- Chemical & pharmaceutical bulletin
- 1979
- 24
Pharmacokinetics of glycyrrhetic acid, a major metabolite of glycyrrhizin, in rats.
- Chemistry, Medicine
- Chemical & pharmaceutical bulletin
- 1989
- 31
Biliary excretion and enterohepatic cycling of glycyrrhizin in rats.
- Biology, Chemistry
- Journal of pharmaceutical sciences
- 1986
- 49
Determination of glycyrrhetinic acid in human plasma by high-performance liquid chromatography.
- Chemistry, Medicine
- Journal of chromatography
- 1991
- 11
Pharmacokinetic profile of glycyrrhizin in healthy volunteers by a new high-performance liquid chromatographic method.
- Chemistry, Medicine
- Journal of pharmaceutical sciences
- 1992
- 94
The metabolism of carbenoxolone in the rat.
- Chemistry, Medicine
- Xenobiotica; the fate of foreign compounds in biological systems
- 1971
- 42
Selective high-performance liquid chromatographic method for the determination of glycyrrhizin and glycyrrhetic acid-3-O-glucuronide in biological fluids: application of ion-pair extraction and fluorescence labelling agent.
- Chemistry, Medicine
- Journal of chromatography
- 1991
- 28
Determination of glycyrrhizin in rabbit plasma by high-performance liquid chromatography with photodiode-array ultraviolet detection and its pharmacokinetics application.
- Chemistry, Medicine
- Journal of chromatography
- 1992
- 3