Analysis and pharmacokinetics of glycyrrhizic acid and glycyrrhetinic acid in humans and experimental animals

  title={Analysis and pharmacokinetics of glycyrrhizic acid and glycyrrhetinic acid in humans and experimental animals},
  author={Stephan Kr{\"a}henb{\"u}hl and Felix Hasler and Reto Krapf},
The disposition of diammonium glycyrrhizinate and glycyrrhetinic acid in the isolated perfused rat intestine and liver.
GZ can be absorbed unchanged from the intestine provided it has sufficient time and is protected from intestinal bacteria, opening up the possibility that the use of pharmaceutical carrier systems or similar formulation approaches may allow effective oral administration of therapeutic levels of GZ without the side effects associated with GA.
Determination of 18β-Glycyrrhetinic Acid in Human Urine After Ingestion of Glycyrrhizin
In this study, a fast and simple analytical method for determination of urinary 18β-glycyrrhetinic acid (18-GA), without any sample purification prior to the analysis, was developed. The method was
Quantitative analysis of Glycyrrhizic acid from a polyherbal preparation using liquid chromatographic technique
A simple, rapid, sensitive and specific reverse phase high performance liquid chromatographic method have been developed for the quantitative estimation of glycyrrhizic acid from polyherbal preparation containing aqueous root extract of Glycyr rhizaglabra using a photodiode array detector.
HPLC Determination of Glycyrrhizic and Glycyrrhetinic acids inWeiyanning granule.
The method established in this paper is simple, accurate and reproducible, which provides a new way for the quality control of Weiyanning Granule.
Separation of Glycyrrhizic Acid and Its Derivants from Hydrolyzation in Subcritical Water by Macroporous Resin
Glycyrrhizic acid (GL) and its derivants, glycyrrhetinic acid 3-O-mono-β-d-glucuronide (GAMG) and glycyrrhetinic acid (GA) hydrolyzed in subcritical water, are bioactive substances and edulcorators.
Influence of honey on the gastrointestinal metabolism and disposition of glycyrrhizin and glycyrrhetic acid in rabbits.
It could be concluded that honey significantly affected the gastrointestinal metabolism of glycyrrhizin and resulted in the increased glycyrrhetic acid exposure and honey might enhance the efficacy and adverse effects of Glycyr rhizin.
A simple method for evaluation pharmacokinetics of glycyrrhetinic acid and potential drug-drug interaction between herbal ingredients
A simple validated high performance liquid chromatography method was developed for the evaluation of the effect of three kinds of active ingredients in traditional Chinese medicine (TCM) on the pharmacokinetics of glycyrrhetinic acid (GA), showing satisfactory precision and accuracy in various stability tests.
The Effects of Sweet Foods on the Pharmacokinetics of Glycyrrhizic Acid by icELISA
The results indicate that honey can postpone the peak concentration of GA in mouse blood, and this effect correlates well with fructose, which provides the valuable information that honey, or fructose, may act as sustained-releasing drugs in clinical scenarios; and that sweet foods may have some influences on drugs when taken together.
Pharmacokinetic Change of Glycyrrhetinic Acid from the Roots and Rhizomes of Glycyrrhiza uralensis by Coadministration with the Rhizomes of Atractylodes japonica, A. macrocephala, or A. chinensis in an Animal Model
  • Jung-Hoon Kim
  • Biology, Chemistry
    Revista Brasileira de Farmacognosia
  • 2020
Atractylodes rhizomes, especially A. japonica, might alter the pharmacokinetic characteristics of glycyrrhetinic acid from G. uralensis when these herbs are coadministered, which provides an understanding for species-specific influences on pharmacokinetics features in herbal combinations.


Rapid estimation of glycyrrhizin and glycyrrhetinic acid in plasma by high-speed liquid chromatography.
A method was established by which glycyrrhizin and glycyrrhetinic acid present in plasma can be extracted with methanol and then separated and determined quantitatively within 10 min by means of high-speed liquid chromatography, and showed that G is absorbed in rat small intestine in an apparent first-order process.
Pharmacokinetics of glycyrrhetic acid, a major metabolite of glycyrrhizin, in rats.
The pharmacokinetics of GLA in the rat is dose-dependent owing to a saturable elimination rate and is accounted for by the intestinal reabsorption ofGLA produced from GLZ and GLA-conjugates during the enterohepatic recycling of both.
Biliary excretion and enterohepatic cycling of glycyrrhizin in rats.
It is concluded that glycyrrhizin was predominantly secreted from the liver into the bile, and that the secondary peaks in the elimination phase, the higher AUC, and the lower CLtot in the control rats were due to the effects of enterohepatic recycling.
Pharmacokinetic profile of glycyrrhizin in healthy volunteers by a new high-performance liquid chromatographic method.
An improved high-performance liquid chromatographic method was developed for the quantification of glycyrrhizin and its metabolites in human plasma and showed biexponential profiles during the 24-h period after administration of each dose.
High Pressure Liquid Chromatography Assay for Determination of 18-β-Glycyrrhetinic Acid in Plasma
Abstract This report presents a useful high pressure chromatography assay for determination of the proposed chemopreventive agent 18-β-glycerrhetinic acid (GA) in murine and human plasma. Drug was
Human Metabolism of Orally Ingested Glycyrrhetinic Acid and Monoammonium Glycyrrhizinate.∗ †
Summary Orally administered glycyrrhetinic acid and monoammonium glycyrrhizinate were poorly absorbed from the gastrointestinal tract as indicated by blood, bile and urine levels of radioactivity.
Pharmacokinetics of glycyrrhizin after intravenous administration to rats.
The results indicate that the pharmacokinetics of glycyrrhizin is nonlinear, and the disposition of drug in plasma at each dose fitted well to a two-compartment pharmacokinetic model.