Analysis and exploration of age-related changes in mammalian structure and function.

@article{Masoro1979AnalysisAE,
  title={Analysis and exploration of age-related changes in mammalian structure and function.},
  author={Edward J. Masoro and Helen A. Bertrand and George U. Liepa and Byung Pal Yu},
  journal={Federation proceedings},
  year={1979},
  volume={38 6},
  pages={1956-61}
}
Although there is a large body of data showing an age-associated decline in the physiological systems of mammals, there is a great need for more descriptive information on the morphological and functional changes that occur with age. A powerful approach for ascertaining the extent to which age-related physiological changes limit the functional capacity of mammals is to study the effects of age on the response to challenges. Food restriction that markedly increases the mean life span of rodents… CONTINUE READING