Analysis and evaluation of channel models: simulations of alamethicin.

  title={Analysis and evaluation of channel models: simulations of alamethicin.},
  author={D. Peter Tieleman and Berk Hess and Mark S. P. Sansom},
  journal={Biophysical journal},
  volume={83 5},
Alamethicin is an antimicrobial peptide that forms stable channels with well-defined conductance levels. We have used extended molecular dynamics simulations of alamethicin bundles consisting of 4, 5, 6, 7, and 8 helices in a palmitoyl-oleolyl-phosphatidylcholine bilayer to evaluate and analyze channel models and to link the models to the experimentally measured conductance levels. Our results suggest that four helices do not form a stable water-filled channel and might not even form a stable… CONTINUE READING

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