This paper proposes a hybrid single carrier sinusoidal modulation suitable for multiphase multilevel inverters. Multiphase multilevel inverters are controlled by hybrid modulation to provide multiphase variable voltage and a variable frequency supply. The proposed modulation combines the benefits of fundamental frequency modulation and single carrier sinusoidal modulation (SC-SPWM) strategies. The main characteristics of hybrid modulation are a reduction in switching losses and improved harmonic performance. The proposed algorithm can be applied to cascaded multilevel inverter topologies. It has low computational complexity and it is suitable for hardware implementations. SC-SPWM and its base modulation design are implemented on a TMS320F2407 digital signal processor (DSP). A Complex Programmable Logic Device realizes the hybrid PWM algorithm and it is integrated with a DSP processor for hybrid SC-SPWM generation. The feasibility of this hybrid modulation is verified by spectral analysis, power loss analysis, simulation and experimental results.