Analysis: A meta-analysis of Early Results to predict Vaccine efficacy against Omicron

@inproceedings{Khoury2021AnalysisAM,
  title={Analysis: A meta-analysis of Early Results to predict Vaccine efficacy against Omicron},
  author={David S. Khoury and Megan Steain and James A. Triccas and Alex Sigal and M. P. Davenport and Deborah Cromer},
  booktitle={medRxiv},
  year={2021}
}
In the studies to date, the estimated fold-drop in neutralisation titre against Omicron ranges from 2- to over 20-fold depending on the study and serum tested. Collating data from the se results in a combined estimate of the fold drop in neutralisation titre against Omicron of 9.7 (95%CI 5.5-17.1). We use our previously established model to predict that six months after primary immunisation with an mRNA vaccine, efficacy for Omicron is estimated to have waned to around 40% against symptomatic… 

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