Analysis, physiological and clinical significance of 12-HETE: a neglected platelet-derived 12-lipoxygenase product.

@article{Porro2014AnalysisPA,
  title={Analysis, physiological and clinical significance of 12-HETE: a neglected platelet-derived 12-lipoxygenase product.},
  author={Benedetta Porro and Paola Songia and Isabella Squellerio and Elena Tremoli and Viviana Cavalca},
  journal={Journal of chromatography. B, Analytical technologies in the biomedical and life sciences},
  year={2014},
  volume={964},
  pages={26-40}
}
While the importance of cyclooxygenase (COX) in platelet function has been amply elucidated, the identification of the role of 12-lipoxygenase (12-LOX) and of its stable metabolite, 12-hydroxyeicosatretraenoic acid (12-HETE), has not been clarified as yet. Many studies have analysed the implications of 12-LOX products in different pathological disorders but the information obtained from these works is controversial. Several analytical methods have been developed over the years to simultaneously… CONTINUE READING
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