Analysing the role of endogenous matrix molecules in the development of osteoarthritis.

@article{Sofat2009AnalysingTR,
  title={Analysing the role of endogenous matrix molecules in the development of osteoarthritis.},
  author={Nidhi Sofat},
  journal={International journal of experimental pathology},
  year={2009},
  volume={90 5},
  pages={463-79}
}
Osteoarthritis (OA) is the most common form of arthritis worldwide. In this condition, damage to the extracellular matrix (ECM) of cartilage occurs, resulting in joint destruction. Factors mediating cartilage damage include mechanical injury, cytokine and superoxide release on a background of genetic susceptibility and obesity. Studies of arthritic cartilage show increased production of ECM molecules including type II collagen, cartilage oligomeric matrix protein, fibronectin (FN) and… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 42 extracted citations

Absorption, distribution and mechanism of action of SYSADOAS.

Pharmacology & therapeutics • 2014
View 4 Excerpts
Highly Influenced

Osteoarthritis and the Complement Cascade

Clinical medicine insights. Arthritis and musculoskeletal disorders • 2018

Reduction of friction by recombinant human proteoglycan 4 in IL-1α stimulated bovine cartilage explants.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society • 2017

References

Publications referenced by this paper.
Showing 1-10 of 108 references

Collagen degradation products modulate matrix metalloproteinase expression in cultured articular chondrocytes.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society • 2006
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…