Analysing the Effect of Mutation on Protein Function and Discovering Potential Inhibitors of CDK4: Molecular Modelling and Dynamics Studies

@inproceedings{Nagasundaram2015AnalysingTE,
  title={Analysing the Effect of Mutation on Protein Function and Discovering Potential Inhibitors of CDK4: Molecular Modelling and Dynamics Studies},
  author={N Nagasundaram and Hailong Zhu and Jiming Liu and V Karthick and C GeorgePriyaDoss and Chiranjib Chakraborty and Luonan Chen and Freddie R. Salsbury},
  booktitle={PloS one},
  year={2015}
}
The cyclin-dependent kinase 4 (CDK4)-cyclin D1 complex plays a crucial role in the transition from the G1 phase to S phase of the cell cycle. Among the CDKs, CDK4 is one of the genes most frequently affected by somatic genetic variations that are associated with various forms of cancer. Thus, because the abnormal function of the CDK4-cyclin D1 protein complex might play a vital role in causing cancer, CDK4 can be considered a genetically validated therapeutic target. In this study, we used a… CONTINUE READING
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SIFT: predicting amino acid changes that affect protein function

  • Nucleic Acids Research
  • 2003
VIEW 11 EXCERPTS
HIGHLY INFLUENTIAL

Evolutionary and structural based computational design to reveal the impact of deleterious missense mutations in Maturity onset diabetes of the young , type 2

C GeorgePriyaDoss, Chakraborty Chiranjib, +3 authors H Zhu
  • Theranostics
  • 2014

Evolutionary and structural based computational design to reveal the impact of deleterious missense mutations in Maturity onset diabetes of the young, type 2. Theranostics 4:366–385

C George Priya Doss, Chiranjib Chakraborty, +3 authors H Zhu
  • doi: 10.7150/thno
  • 2014