Analysing biological pathways in genome-wide association studies

@article{Wang2010AnalysingBP,
  title={Analysing biological pathways in genome-wide association studies},
  author={Kai Wang and Mingyao Li and Hakon Hakonarson},
  journal={Nature Reviews Genetics},
  year={2010},
  volume={11},
  pages={843-854}
}
Genome-wide association (GWA) studies have typically focused on the analysis of single markers, which often lacks the power to uncover the relatively small effect sizes conferred by most genetic variants. Recently, pathway-based approaches have been developed, which use prior biological knowledge on gene function to facilitate more powerful analysis of GWA study data sets. These approaches typically examine whether a group of related genes in the same functional pathway are jointly associated… CONTINUE READING
Highly Influential
This paper has highly influenced 32 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 412 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 116 references

Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects

  • K Wang
  • Hum. Mol. Genet
  • 2010

Similar Papers

Loading similar papers…