Analysing biological pathways in genome-wide association studies

  title={Analysing biological pathways in genome-wide association studies},
  author={Kai Wang and Mingyao Li and Hakon Hakonarson},
  journal={Nature Reviews Genetics},
Genome-wide association (GWA) studies have typically focused on the analysis of single markers, which often lacks the power to uncover the relatively small effect sizes conferred by most genetic variants. Recently, pathway-based approaches have been developed, which use prior biological knowledge on gene function to facilitate more powerful analysis of GWA study data sets. These approaches typically examine whether a group of related genes in the same functional pathway are jointly associated… CONTINUE READING
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