Analyses of the recycling receptor, FcRn, in live cells reveal novel pathways for lysosomal delivery.

@article{Gan2009AnalysesOT,
  title={Analyses of the recycling receptor, FcRn, in live cells reveal novel pathways for lysosomal delivery.},
  author={Zhuo Gan and Sripad Ram and Carlos Vaccaro and Raimund J. Ober and E. Sally Ward},
  journal={Traffic},
  year={2009},
  volume={10 5},
  pages={
          600-14
        }
}
Lysosomes play a central role in the degradation of proteins and other macromolecules. The mechanisms by which receptors are transferred to lysosomes for constitutive degradation are poorly understood. We have analyzed the processes that lead to the lysosomal delivery of the Fc receptor, FcRn. These studies provide support for a novel pathway for receptor delivery. Specifically, unlike other receptors that enter intraluminal vesicles in late endosomes, FcRn is transferred from the limiting… CONTINUE READING

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