Analyses of lindane, vinclozolin, aldrin, p,p'-DDE, o,p'-DDT and p,p'-DDT in human serum using gas chromatography with electron capture detection and tandem mass spectrometry.

@article{Fras2001AnalysesOL,
  title={Analyses of lindane, vinclozolin, aldrin, p,p'-DDE, o,p'-DDT and p,p'-DDT in human serum using gas chromatography with electron capture detection and tandem mass spectrometry.},
  author={Mercedes Moreno Fr{\'i}as and Antonia Garrido Frenich and Jos{\'e} Luis Mart{\'i}nez Vidal and M Mateu S{\'a}nchez and Francisco Olea and Nicol{\'a}s Olea},
  journal={Journal of chromatography. B, Biomedical sciences and applications},
  year={2001},
  volume={760 1},
  pages={1-15}
}
A sensitive, selective and reliable procedure was developed and validated to determine organochlorinated compounds, which present endocrine-disrupting effects, lindane, vinclozolin, aldrin, p,p'-DDT, o,p'-DDT and p,p'-DDE, in human serum. The analytical methodology combines serum extraction with organic solvents, clean-up of the organic extract using acid treatment with H2SO4, elution of the cleaned-up extract through liquid column chromatography system and analysis of the fraction eluted by… CONTINUE READING
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