Analyses of gating thermodynamics and effects of deletions in the mechanosensitive channel TREK-1: comparisons with structural models.

Abstract

TREK-1, a mechanosensitive K channel from the two-pore family (K(2)P), is involved in protective regulation of the resting potential in CNS neurons and other tissues. The structure of TREK-1 and the basis of its sensitivity to stretch and variety of lipid-soluble factors remain unknown. Using existing K channel structures as modeling templates, TREK-1 was… (More)

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@article{Maksaev2011AnalysesOG, title={Analyses of gating thermodynamics and effects of deletions in the mechanosensitive channel TREK-1: comparisons with structural models.}, author={Grigory Maksaev and Adina L Milac and Andriy Anishkin and H. Robert Guy and Sergei Sukharev}, journal={Channels}, year={2011}, volume={5 1}, pages={34-42} }