Analyses of cross species polymerase chain reaction products to infer the ancestral state of human polymorphisms.

@article{Iyengar1998AnalysesOC,
  title={Analyses of cross species polymerase chain reaction products to infer the ancestral state of human polymorphisms.},
  author={Sudha K. Iyengar and Michael P Seaman and Amos S. Deinard and Howard C. Rosenbaum and Giorgio Sirugo and C. Castiglione and Judith R. Kidd and Kenneth K. Kidd},
  journal={DNA sequence : the journal of DNA sequencing and mapping},
  year={1998},
  volume={8 5},
  pages={317-27}
}
In numerous population genetic and disease association studies decisions about the ancestry of polymorphic alleles are often made based on the relative frequency of the alleles in the extant populations with the most frequent allele being deemed as ancestral. However, the frequency of an allele in a population is generally not a perfect indicator of its ancestral status. A more accurate method to assess ancestral/derived status of polymorphic alleles involves identification of shared alleles… CONTINUE READING

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