Analyses of copy number variation reveal putative susceptibility loci in MTX-induced mouse neural tube defects.

Abstract

Copy number variations (CNVs) are thought to act as an important genetic mechanism underlying phenotypic heterogeneity. Impaired folate metabolism can result in neural tube defects (NTDs). However, the precise nature of the relationship between low folate status and NTDs remains unclear. Using an array-comparative genomic hybridization (aCGH) assay, we… (More)
DOI: 10.1002/dneu.22170

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