Analyses of aqueous humour ghrelin levels of eyes with and without glaucoma.

  title={Analyses of aqueous humour ghrelin levels of eyes with and without glaucoma.},
  author={A Rocha-Sousa and P Alves-Faria and In{\^e}s Falc{\~a}o-Pires and Fernando Manuel Falc{\~a}o-Reis and Adelino F Leite-Moreira},
  journal={The British journal of ophthalmology},
  volume={93 1},
Ghrelin is an acylated, 28-amino-acid peptide isolated from human and rat gastric oxyntic mucosa, with actions mediated by the GHSR-1a receptor. The ability of ghrelin to activate GHSR-1a is dependent on the presence of an octanoyl-(acyl)-chain in serine-3. As almost 90% of circulating ghrelin lacks this chain and this desacylated form (des-acyl-ghrelin) has biological effects, this means that these effects are not mediated by GHSR-1a. The presence of ghrelin in the rat posterior epithelium of… CONTINUE READING

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